Clinical and immunological manifestations in 134 Puerto Rican patients with systemic lupus erythematosus
Identifieur interne : 002686 ( Main/Exploration ); précédent : 002685; suivant : 002687Clinical and immunological manifestations in 134 Puerto Rican patients with systemic lupus erythematosus
Auteurs : L M Vilá ; A M Mayor ; A H Valentín ; M. García-Soberal ; S. Vilá [Porto Rico]Source :
- Lupus [ 0961-2033 ] ; 1999-05.
English descriptors
- Teeft :
- Anemia leukopenia lymphopenia thrombocytopenia, Anticardiolipin, Anticardiolipin antibodies, Antiphospholipid syndrome, Arthritis, Arthritis rheum, Better knowledge, Cardiac involvement, Caribbean island, Clinical evidence, Clinical manifestations, Corticosteroid, Curacao patients, Current study, Cutaneous, Cyclophosphamide, Demographic parameters, Diagnostic criteria, Discoid lupus, Disease activity, Disease expression, Erythematosus, Ethnic groups, Genetic background, Great intensity, Hispanic, Hispanic population, Immunologic, Immunologic manifestations, Immunosuppressive agents, Immunosuppressive drugs, Internal medicine, Lupus, Lupus anticoagulant tests, Lupus erythematosus, Major organ damage, Malar, Malar rash, Male patients, Male ratio, Manifestation, Medicaid insurance, Nephrotic syndrome, Neurologic manifestations, Oral cyclophosphamide, Other hand, Other populations, Other studies, Pharmacologic treatment, Pharmacologic treatments, Photosensitivity, Prospective study, Puerto rican, Puerto rican patients, Puerto ricans, Puerto rico, Pulse cyclophosphamide, Rash, Renal, Renal involvement, Rheum, Rheumatoid factor, Rican, Ricans, Risk factors, Semin arthritis rheum, Serologic, Serologic manifestations, Serologic tests, Socioeconomic status, Study population, Syndrome, Systemic, Systemic lupus erythematosus, Vila.
Abstract
To gain a better understanding of systemic lupus erythematosus (SLE) in Puerto Ricans we studied the clinical and serologic manifestations in a cohort of 134 patients. The female to male ratio was 18: 1. Mean age at diagnosis was 32 12 y. The mean duration of disease and follow-up were 7.4 6.0 and 5.8 6.0 years respectively. Mortality was 3%. Photosensitivity (76.9%) and malar rash (71.9%) were the most common clinical manifestations. Arthritis was observed in 67.5% of patients. Anemia was seen in 67.2% of patients, but only 12.7% had autoimmune hemolytic anemia. Leukopenia (41.8%) and lymphopenia (64.9%) were also common. Serositis was observed in only 28%. Severe kidney damage such as nephrotic syndrome (14.2%) or renal failure (4%) was infrequent. Cardiovascular (12.7%) and neurologic (9.0%) manifestations were also uncommon. Antinuclear antibodies (ANA) were detected in 93.3%, anti-dsDNA antibodies in 54.5%, anti-Ro antibodies in 30.1% and anti-La antibodies in 14.2%. Low C3 and low C4 were observed in 38.3% and 35.7% respectively. This study suggests that Puerto Ricans with SLE present a mild form of disease predominantly manifested by cutaneous, musculoskeletal and hematologic involvement, but low prevalence of major organ damage and low mortality.
Url:
DOI: 10.1191/096120399678847803
Affiliations:
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Le document en format XML
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<term>Better knowledge</term>
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<front><div type="abstract" xml:lang="en">To gain a better understanding of systemic lupus erythematosus (SLE) in Puerto Ricans we studied the clinical and serologic manifestations in a cohort of 134 patients. The female to male ratio was 18: 1. Mean age at diagnosis was 32 12 y. The mean duration of disease and follow-up were 7.4 6.0 and 5.8 6.0 years respectively. Mortality was 3%. Photosensitivity (76.9%) and malar rash (71.9%) were the most common clinical manifestations. Arthritis was observed in 67.5% of patients. Anemia was seen in 67.2% of patients, but only 12.7% had autoimmune hemolytic anemia. Leukopenia (41.8%) and lymphopenia (64.9%) were also common. Serositis was observed in only 28%. Severe kidney damage such as nephrotic syndrome (14.2%) or renal failure (4%) was infrequent. Cardiovascular (12.7%) and neurologic (9.0%) manifestations were also uncommon. Antinuclear antibodies (ANA) were detected in 93.3%, anti-dsDNA antibodies in 54.5%, anti-Ro antibodies in 30.1% and anti-La antibodies in 14.2%. Low C3 and low C4 were observed in 38.3% and 35.7% respectively. This study suggests that Puerto Ricans with SLE present a mild form of disease predominantly manifested by cutaneous, musculoskeletal and hematologic involvement, but low prevalence of major organ damage and low mortality.</div>
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